ADAPTABLE Study Aspirin Dosing: A Patient-centric Trial Assessing Benefits and Long-term Effectiveness

ADAPTABLE Study Aspirin Dosing: A Patient-centric Trial Assessing Benefits and Long-term Effectiveness

Lead Principal Investigator: Matthew Roe, MD, MHS

Organization:  Duke University

Funded through a Patient-Centered Outcomes Research Institute (PCORI) Award (ASP-1502-27079).

ADAPTABLE Study Aspirin Dosing: A Patient-centric Trial Assessing Benefits and Long-term Effectiveness

Lead Principal Investigator: Matthew Roe, MD, MHS

Organization:  Duke University

Funded through a Patient-Centered Outcomes Research Institute (PCORI) Award (ASP-1502-27079).

Overview

aspirin pills  aspirin pills

To compare two doses of aspirin (81 mg and 325 mg) in up to 20,000 high-risk patients with atherosclerotic cardiovascular disease

network

Enrollment as of 3/5/2017: 1,882 across 24 sites

broken heart

The optimal dose of aspirin has the potential to prevent 19,000 deaths from heart attacks

who's involved?

Participating Networks: MidSouth CDRN, CAPriCORN, REACHnet, GPC, NYC-CDRN, PaTH, OneFlorida, pSCANNER, Health eHeart Alliance

hospital

35 Health Systems

participants

Adaptors Team (8 patient representatives)

how we're making a difference

Working with the study team, Adaptors were involved in the prioritization of the research topic, protocol design, study portal creation, and materials development. Adaptors participate in investigator meetings, sit on the steering committee and work groups, and will be instrumental in the results dissemination plan. 

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Created an electronic platform for recruiting patients into clinical trials efficiently with e-identification, e-consent, and e-randomization
Cost per enrolled patient has come down by an order of magnitude
ADAPTABLE = $850
Compared with
3 Simple, NIH Pragmatic Trials: $2,260 to $13,269
Industry Trials: $8,500 to $10,000