Short and Long-term Effects of Antibiotics on Childhood Growth

Short and Long-term Effects of Antibiotics on Childhood Growth

Lead Principal Investigator: Jason Block, MD, MPH

Organization: Harvard Pilgrim Health Care, Inc.,

Purpose: To assess the association between antibiotic use in the first two years of life and weight outcomes in later childhood, with a comparative assessment of different types, amounts, and timing of antibiotics.

Funded through a Patient-Centered Outcomes Research Institute (PCORI) Award (OBS-1505-30699).

Short and Long-term Effects of Antibiotics on Childhood Growth

Lead Principal Investigator: Jason Block, MD, MPH

Organization: Harvard Pilgrim Health Care, Inc.,

Purpose: To assess the association between antibiotic use in the first two years of life and weight outcomes in later childhood, with a comparative assessment of different types, amounts, and timing of antibiotics.

Funded through a Patient-Centered Outcomes Research Institute (PCORI) Award (OBS-1505-30699).

Overview

kids

A cohort of approximately 700,000 children, including more than 360,000 with five years of follow-up data and more than 60,0000 with 10 years of follow-up data
The study teams have collected de-identified individual-level data on this cohort of children and are in the process of analyzing data collected
Focus group activities for the study’s secondary aim looking at parent/caregiver experiences with antibiotic use in young children are complete and analysis of the data is underway

who's involved?

sites

14 participating Networks: ADVANCE, CAPriCORN, GPC, Mid-South CDRN, NYC-CDRN, OneFlorida, PEDSnet, PORTAL, REACHnet, SCILHS, CENA, SAPCON, IAN, DuchenneConnect
38 institutions providing data

hospital

how we're making a difference

Helped to develop new query tools which will assist future PCORnet studies in performing study-specific data characterizations
First to examine PCORnet prescribing tables in detail and helped to remediate issues found

antibiotics

Largest study to date to examine the relationship between antibiotics and weight outcomes in childhood